- Akali: Trained since she could walk to be a master assassin, surpassed her mother in skill in a few years with her mother training to be a master ninja for decades to reach her current level, has such precise knowledge of ways to kill that she knows every single pressure point in the human body and can pinpoint hit them from across a room filled with thick smoke, and is so skilled that despite having no magic or supernatural powers whatsoever she's considered equally as lethal as guys who can manipulate lightning, control shadows, and cut space.
- Shen (League of Legends): Trained since birth to be a master ninja with a specialty in hyperanalysis precise enough to, in a crowded, busy ballroom, instantly deduce that a target was half a finger length too far way for him to be able to attack the moment he saw his target, despite said target being a master of stealth able to disguise himself with shadow ninjutsu techniques and actively avoiding detection.
- Kay: Is skilled to the point that he mastered every single weapon used in martial arts in an extremely short amount of time, whereas it normally takes people several years of training to become proficient in a single weapon, and is so skilled in hand-to-hand combat that he can fight barehanded to the same if not a greater proficiency and willingly did so before he found his signature scythe, and also learned mastered shadow ninjutsu in weeks where normal students require years just to learn the basics.
- Yasuo: Learned Wind Style, a form of natural wind manipulation that is so close to actual magic that his techniques were mistaken for an actual wind magic attack, through sheer skill without using any magic and was the only person in a generation to master it as just a child. He is also able to, with just a few glances at a person even while he is fighting three other people at the same time, break down a person's entire fighting style with all of their strengths and weaknesses even if that person is vastly more skilled than himself.
- Lee Si: Is a master of Ionia's martial arts, and just by listening to the movement and breathing of three men he was able to determine that one had lung disease, one had a weak heart that would give out in less than a year, and one had an injured spine that forced him to walk slightly more on his left side. He can also detect even the slightest of flaws in the fighting styles of any opponent just by listening to them fight.
- Rive is a highly skilled swordswoman, having trained since childhood in swordsmanship and having the natural skill to quickly learn how to wield a blade larger than herself with deadly efficiency. Her skill is such that the Noxian High Command even recognized her as one of their most skilled soldiers, granting her a runic sword enchanted by LeBlanc to wield in combat, something that is only done for the best of the best of the best (With the Noxian military being tens of millions strong). Even years after her self-exile after the end of the Noxian occupation of Ionia she retained her skill, having kept up with a swordsman as skilled as Yasuo blow for blow in single combat.
- Katarina Du Couteau: is credited as being one of the most skilled and deadliest blade masters in all of Valoran, able to match Garen Crownguard (The greatest swordsman in the nation of Demacia) blow for blow on multiple occasions. She is a highly proficient and elite assassin, having been hand picked by Swain, and she is capable of using virtually anything as a tool to kill someone with. She is also a master of controlling her environment, having extensive knowledge of misdirection tactics, a mastery of how to use the enemy's instincts against them, and a highly adaptive combat style that has allowed her to take on multiple opponents in direct combat on multiple occasions.
- Talon (League of Legends): Is widely recognized as being only slightly less skilled than Katarina, with dozens of Noxus' best assassins being outskilled and killed by him due to him being seen as a threat to Noxus as a whole (As in people who can eat memories and absorb souls with their presence alone viewed him as a massive threat).
- Hecarim: Is a master of all forms of combat and warfare known to mankind.
- Kalista: Outmatched Hecarim in a bout of skill.
- Khada Jhi: Is such a skilled sniper that he is unhindered by a mask that both constricts his breathing and removes his depth perception, which would normally cripple even a master sniper.
- Master Yi is one of the most skilled practitioners of Wuju Style, a martial art which requires an immense amount of patience and strategy, centered around analyzing the opponent for any openings or weaknesses before killing them with a single cut, and he's been described as never attacking until landing a strike on his opponent was absolutely guaranteed.
- Wukong: Mastered Wuju Style in a very short time period, something that took Master Yi several dozen years to master, and became so skilled in the art to the point where he was even able to outsmart Yi a few times.
- Jarvan IV: Wields Drakesbane, a weapon that is literally a 6 foot extendable lance covered in giant revolving razor blades that is described as being just as lethal to the wielder as it is to the opponent if the wielder is anything less than a master spear wielder, to such a high degree of skill that he surpassed Xin Zhao, a man who spent decades becoming a master spear wielder and who needed years of daily training to be able to properly wield, in only a few months, with even Xin himself saying that Jarvan's skill far outstrips his own.
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