There's a bunch.
A lot of Vanilla Expanded, most notably Psycasts, Factions, Vehicles, and Weapons. Alpha Animals, Empire, Large Faction Bases, a variety of xenotype mods, Rim Cities, Fortifications, Hospitality, Dire Raids, Go Explore, Megafauna, More Mechanoids, Rah's Bionics and Surgery, More Persona Traits, Advanced Bionics Expansion, Combat Bionics, Warhammer 40k weaponry, Weapons+, War Crimes Expanded, Royal Arsenal, and Altered Carbon are the main content adding mods, the others just add singular changes/items/fixes.
You can, but like I said, this playthrough will probably wrap up here soon enough: I want to finish the road system before I complete it. After that I'll probably begin a fantasy Rimworld run later under the same pretense. Give me your pawn's info, and I'll slap it in.