Well i did not say there would not be any consequence. This is what i said in one of the scenarios "he uses some blood to heal the poison away" Basically i acknowledge that the poison would affect Denji initially but he would heal it away similar to how i would assume he would be able to heal cancer away. The main part of your argument hinges on the "cursed" part of the poison being supernatural in nature. Aside from that the mahito arguments about the soul is weird because JJK has a weird definition for the soul but for some reason that definition needs to be enforced to other verses who might have different definitions for souls or lack souls (CSM) It is hard to argue that soul attacks would work on CSM humans as at least to me it doesn't seem like humans in CSM actually have souls. I need an argument for why they have souls because all evidence points to them lacking souls. you mentioned cursed and magical poison in the same sentence. What makes the poison magical other than it being cursed? I guess a good way to interpret this is while the poison is "supernatural" what are the actual effects is the poison doing to Denji's body? If the poison is simply maybe corroding his body, maybe melting organs or any other kind of damage of similar effect then yes Denji absolutely heals from the "supernatural poison" The only thing that would happen is Denji would take initial lingering damage but then his healing factor would out heal the blood damage. Denji doesn't need to resist or adapt to the poison. He simply has to out-heal the poison which i believe he does. As for the soul attacks CSM's definition of the soul is that they lack souls so it's hard to say if the soul damage aspect would even work realistically. While there's a lot of conceptual stuff in CSM none of that equals explicit soul definition in anyway. Also DB at least would acknowledge Pochita and Denji's metaphysical bond is not soul related at all it's conceptual which doesn't necessarily equal there being souls involved at all contracts are metaphysical or conceptual based. Soul damage cannot be granted being able to affect a contract or metaphysical / conceptual stuff. Naturally it only affects Soul related conceptual stuff and contracts aren't soul based at all. While Deadpool has a better healing factor I want to use him as an example. Yes Yuji's blood would affect Deadpool but Deadpool would simply out heal the blood, he doesn't need resistances or adaptability to do it even if he has resistances or adaptability. So I agree that Yuji's blood would affect Denji I don't believe it would have any relevant lasting effect on Denji because he would just out-heal the actual effects of the blood in the first place. As for soul based damage CSM has a lot of conceptual stuff in it with the devils and contracts but nowhere inside CSM is a definition or even evidence for a soul of any kind for humans. Devils have reincarnation but i would argue that doesn't confirm a soul instead it is simply a metaphysical / conceptual process of being a devil like how devils are manifested from humans fears their existence is from human thoughts. I don't know if i covered everything but my laptop crashed and windows forced an update on me even though my updates were paused so... I'll try to address any follow ups you might have.
I get where you’re coming from, but I think there’s a couple things being overlooked here.
First, Yuji’s blood manipulation poison is not just “normal biological damage” like cancer, acid, or organ failure. In JJK, the poison aspect comes specifically from cursed energy interacting with the target’s body. Eso and Kechizu’s blood explicitly poisons through cursed techniques, and Choso’s blood retains the same cursed properties because Death Painting blood is inherently tied to cursed energy. That’s why characters with absurd durability still get affected by it. The series treats it as supernatural toxicity, not just chemistry.
And importantly, regeneration in fiction doesn’t automatically negate supernatural poison unless the character has shown resistance to that specific type of effect. Denji can regenerate from physical destruction by consuming blood, absolutely. But we’ve also seen limits and conditions on that healing repeatedly. He still suffers ongoing damage, can be incapacitated, and needs external blood intake to keep going at high levels. Even characters like Deadpool, who you brought up, are regularly affected by poisons, curses, viruses, and supernatural afflictions despite healing from the damage afterward. “Healing through it” and “being immune to it” are two different things.
The bigger issue is that Yuji’s attacks later on are not just poison-based anyway. Once soul-targeting enters the discussion, CSM not explicitly explaining souls does not equal “souls do not exist.” The series literally has:
- consciousness persistence after death,
- reincarnation cycles for devils,
- contracts that bind existence/metaphysical identity,
- mind/spirit interactions,
- Hell as an actual metaphysical realm,
- and beings retaining identity across reincarnation cycles.
That is already enough for crossverse standards like VS Wiki or Death Battle to acknowledge a soul/spiritual framework exists. JJK’s soul mechanics are more explicitly defined, yes, but crossverse debating doesn’t require identical cosmology definitions. Otherwise half of fiction couldn’t interact.
Mahito’s technique is also important here because it directly distinguishes the body from the soul. Yuji being able to damage Mahito means Yuji can interact with souls on some level. Sukuna also explicitly perceives and understands the soul. Later material continues reinforcing Yuji’s soul-targeting capability. So the argument isn’t “contracts = souls,” it’s that CSM clearly has metaphysical existence layers while JJK has explicit soul interaction mechanics.
Also, Denji’s regen has never shown resistance to attacks that specifically target existence on a spiritual/metaphysical level. Meanwhile JJK repeatedly establishes that soul damage bypasses conventional durability and regeneration unless the soul itself can be perceived or repaired. Mahito outright says the shape of the body follows the shape of the soul. That’s why transfigured humans can’t simply regenerate back normally.
So yeah, Denji could absolutely heal some of the physical damage caused by the blood initially. I don’t think anyone denies that. The disagreement is whether he can continuously outheal cursed poison + soul-targeting damage with no demonstrated resistance to either. And based on canon from both series, I don’t think there’s enough evidence to confidently say he can.
Especially in VS debating, “the verse never explicitly says the word soul” usually isn’t enough to argue complete immunity to soul-based interaction when the setting blatantly contains metaphysical identity, afterlife systems, reincarnation, contracts, and spiritual existence.