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Because of his immortality, Future Zamasu felt no pain. This was shown when he got impaled with Trunks' sword and he pulled it out while saying "It doesn't hurt." This was also shown when he was unharmed when Goku Black attacked through him to hurt Goku and Zamasu didn't even react to being impaled with the ki blade. As Fusion Zamasu, he lost this, which was commented on when he felt pain from Vegito's Shining Sword attack.