Iirc, the context of the conversation was in regards to the Shinju. Koji told Boruto to retreat and Boruto didn’t immediately retreat. When he started to get packed out, Koji pleaded with him to retreat again, telling him if he goes does it’s the end of everything. When Boruto finally retreats and Koni meets him at the Sasuke Tree (
) he makes the “Are you trying to Destroy this world?” Comment but the overall context is still in regard to Shinju.
It seriously doesn’t seem like Uzuhiko was the reference. And depending on the threat level of the Shinju “overall”, Koji’s statement could be potentially viewed as “Are you trying to destroy this Reality/Universe?” And I don’t think it’s too far-fetched given the inclusion of Reality/Universe altering abilities like Omnipotence.
At this point, everything really hinges on what Koji “Saw”. Maybe he somehow gained the ability to see the future like the Toad Sage(?).