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In my theory, Saitama's power is basically narrative trying to make anything they try against him useless, making him always the strongest. All the things the Garou tried against him didn't work, such as martial arts, an attack that negates durability by hitting the organs, dimensional portals he kicked and caught, power mimicry that became useless over time, etc. So, Saitama would be immune to any hax from his verse, as the narrative would always make that hax useless against him. Basically Saitama could do whatever he wants as long as he wants, like not needing oxygen to survive in space. So if there was a being that had soul manipulation or transmutation, narrative would make it useless against him.