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Still, Dante can damage its core, which if it scales to DMC5 Nightmare, is its soul.Theglassman12 said:@Knight damaging the cores isn't the only way to harm Nightmare. Breaking out of his evil dimension where he makes you fight an old boss is you damaging it despite the core not being exposed
It's also possible that the dimension is tied to his soul/core, and Dante breaking out of the dimension damages the soul/core indirectly.