No, for Omega they said he would destroy the entire galaxies (if you saw GT then you should know how ginga was used to describe the cosmos of the universe like the Super manga), and Elder Kai even had to add it as an extra detail that it would reach the Kaioshin Realm even after it was mentioned the cosmos would be destroyed.
GT clearly shows how the Afterlife is a completely different place from the entire universe.
The Kaioshin Realm was never part of any universe or macrocosm in DBZ and was it’s own place from it.