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aizen is in his third fusion.Aizen has access to The Hogyoku as stated in the OP, which means we're using the version of Aizen who is Fused with it, but hasn't undergone any transformations. He possesses the regenerative ability and evolutionary ability of The Hogyoku. So, anything Sasuke does won't kill Aizen, and Aizen will eventually evolve into his Tier 4 keys and gain resistances to everything Sasuke has, similar to how he did with The Kototsu.
It's a stomp for Aizen unless you restrict The Hogyoku.