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It says mayuri doesn't have a weakness which isn't true and he is a sadistic person who likes to toy with the lives of people and turning them into test research subjects. During soul society arc he used those unamed soul reapers to trap the ryoukas and exploding them if they did not succeed with their plan and using nemu to hold on to Ishida and using her to get to him by injuring her and the sword passing through her body his uryu ishida's bodyand he succeeded in injuring him as while she was hugging him before she decided to let go which prevented him from doing further damage to him through her body.