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It is not very difficult, Zeref can get out of the genjutsu effect by passively rewinding time. Also, if I remember correctly, in the wiki it is considered mid godly regen>layered mind/soul manipulation. (I am not sure) Also, thanks to Zeref's paralysis manipulation, Itachi will be paralyzed as soon as he sees Zeref. And since the speeds are equal, Zeref can kill Itachi directly thanks to Anksheram. Also, thanks to Anksheram, Zeref killed Mavis, who had immortality type 7, so immortality type 7 is not an obstacle for Zeref. Even these are enough for Itachi, I didn't feel the need to scan as everything is in the profile. If the discussion continues, I will be here.Anyway, due to the reasons I wrote and the defenses made above, ZEREF FRA