Misako has trained with the Lee Brothers, both of which created their own styles of martial arts, and were able to combat an undead sorcerer and countless members of the supernaturally enhanced Black Dragon Clan. Abobo, a frequent rival to the Lee Brothers, was beaten by Misako. Misako lives in River City where nearly every confrontation ends in a street battle. She has conquered witches like Blaire who was a prodigy in the mystic arts since she was just 8, people with otherworldly sci-fi technology like Tsuiko, the power of rock and roll, ghosts, and yes, the yakuza. Said yakuza has the resources to create super soldier serums, upgraded members and cyborgs that are capable of learning from past failures and growing stronger based on how their opponent attacks, and Misako showed zero signs of struggle with any of them, clearing out entire facilities and towers of them in a single night. Every single one of these opponents has their own styles of fighting, whether being usage of scattershot-styled projectiles, wrestling, blade-wielding with crazy elemental strikes, ninja techniques, breakdance-styled combat, etc, and she is able to adapt and conquer them through skill and power. Misako grows stronger and learns new techniques just by attacking people. And when she had gotten lazy over the course of months and forgotten all of her skills, she got them all back in a single day. Combine this with her advantages like her accessories being able to put someone out of commission through punch-based status effects, speed amps, and potentially resurrecting with her Lanterns, and she's not going down without a fight.