Durability wise, he is ~15 tons with Executioner of steel, has a passive forcefield around him that can block his own normal attacks without a scratch (>10 tons), and has another active forcefield that can block an attack that could vaporize him, and that attack is stronger than him with his buffs (>70 tons)
Basically, >70 tons for attack potency, and >15 tons for durability. I have to mention, though, he constantly gets stronger.
As for dodging, i mean he is skilled, but I kinda need to see a vid of Isaac's danmaku. Though, a few questions first. 1st, is it magic? 2nd, what is the range of the danmaku? Is it tens of meters at its peak? And 3rd, can isaac negate High-Mid regen?
Isaac massively massively upscales from 18 tons (a bunch of multipliers scaling chains and other stuff that I cannot go into in short order because there is straight-up just too much shit) along with having multiple passive sources of damage including toxic shock which deals twice isaac's ap match start.
(funnily enough, Isaac could also given razor + pyro and a couple of other items letting him infinitely charge and use his space bars for infinite AP)
At match start (not even firing a single tear or charging up one) isaac can cause
this, and it only gets worse when he charges a shot up or tries to shoot (the game normally crashes at that point, so lmao). No, it isn't, the most you could call magic is maybe the tarot cards and even that is an eh. It's tens of meters at its peak yeah.
He feasibly can't, but he does have ways around such as literally just destroying him so bad he can't regen from it or if he somehow manages to land either a chaos card (which kills any enemy in the game (including stone ones) to the point that if there are any remains of them, they are v.frag'd or just blood) or eraser (history ee)
He also has a couple of stuff I would like to note, such as:
Gnawed leaf which makes him invulnerable (not actual invul) to anything in-universe, including his own stuff, which without a couple of immunities (and even with) can harm or outright kill him
Like 12+ mid-godly resurrections and more based on his own luck (that is effectively maxed)
Holy Mantle gives him protection from the first hit landed against him
Incubus which travels around giving isaac an even greater AP while also harming those in its aura (though it is pretty small)
Multiple familiars that scale to his own AP, shoot out his own tear barrage, and a few that will attempt to melee yoon (though it likely won't do much)
Several auras around him that passively damage folk within them
His tears have their own auras that scale to their size/damage and have passive damage
Will literally neg diff any attempts at range play through a combination of slowing down any projectiles that get close, deleting said projectiles, his tears also delete projectiles they come in contact with.
If we really want to get fucky TMTRAINER literally warps data and reality for every future item isaac can pick up (which he can spawn more of via his space bar (don't get me started on the long ass list of space bar items) which can induce various effects that I really don't want to get into as they are straight up random and I literally have no idea what the list of this thing's effects or conditions are and I am not looking them up
Prolly more I am forgetting