Resistance question

[I'm_Blue_daba_dee_daba_die]

Say you have Character A who resists a 3D ability with 999999999999999 layers of resistance. If Character B with the same ability on a tier 1 scale shows up, but he has no resistance negation or showings that he can overwhelm characters with resistances, would Character B be able to affect Character A???

Another question is if someone resists Tier 1 powernull, would he be able to resist 3D conceptual Powernull???