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What happens is in episode 2 of AT, LSP bites Jake and he gets "the lumps" a sickness which changes Jake into a Lumpy Space being. The biological manipulation here is that he changes from a magic dog to part of the Lumpy Space species.
https://www.cartoonsons.com/cartoons/watch/id/adventure-time-tv-series/season/1/episode/2
https://adventuretime.wikia.com/wiki/Trouble_in_Lumpy_Space/Transcript
Jake: AAAAAGH!
Lumpy Space Princess: [Muffled:] Oh. Sorry I bit your leg.
Jake: You're still biting me!!
Lumpy Space Princess: Oh, my gosh. Oh, right. Sorry.
Fin: Dude! Your leg!
Jake: This is... new. It's nothin' ominous, though. Just a bump.
Lumpy Space Princess: Nah, that's no bump. It's the early stage of the lumps.
Fin: Is it serious?
Lumpy Space Princess: It just means he's changing into a Lumpy Space guy, on account of my bite. It's just like, um, y'know... werewolf rules? [Imitating a werewolf] Ar, rawr rawr rawr rawr rawr rawr!
Fin: Oh, no!
Jake: What? You think I'm gonna turn all lumpy like her? Get outta here. [Arm suddenly lumps up] Wha? Finn, I think I'm freakin' out!
https://www.cartoonsons.com/cartoons/watch/id/adventure-time-tv-series/season/1/episode/2
https://adventuretime.wikia.com/wiki/Trouble_in_Lumpy_Space/Transcript
Jake: AAAAAGH!
Lumpy Space Princess: [Muffled:] Oh. Sorry I bit your leg.
Jake: You're still biting me!!
Lumpy Space Princess: Oh, my gosh. Oh, right. Sorry.
Fin: Dude! Your leg!
Jake: This is... new. It's nothin' ominous, though. Just a bump.
Lumpy Space Princess: Nah, that's no bump. It's the early stage of the lumps.
Fin: Is it serious?
Lumpy Space Princess: It just means he's changing into a Lumpy Space guy, on account of my bite. It's just like, um, y'know... werewolf rules? [Imitating a werewolf] Ar, rawr rawr rawr rawr rawr rawr!
Fin: Oh, no!
Jake: What? You think I'm gonna turn all lumpy like her? Get outta here. [Arm suddenly lumps up] Wha? Finn, I think I'm freakin' out!