Assuming Lee has access to his standard weapons and abilities from the game, he may have a chance to defeat the bear, but it's still unlikely
Even with the advantage of landing the first attack, it's highly unlikely that Lee would be able to incapacitate or kill the grizzly bear. Grizzly bears are incredibly resilient and powerful animals capable of withstanding a significant amount of damage. Even if Lee were to land a strong blow with a weapon, it's doubtful that it would be enough to take down the bear
Additionaly, Grizzly Bears have powerful jaws and claws that can cause significant damage to their opponents. If Lee were to get withing range of the bear's attacks, he would likely be seriously injured or killed.
Therefore, its highly likely that the grizzly bear would emerge victorious in this scenario. While Lee is a skilled survivor and fighter he would be at a significant disadvantage when facing off against a real-world grizzly bear in a one on one fight....