@Oloserian
Not really. Kryptonian physiology is different, but they still have a heart and brain in the exact same places as most humanoid species. They've never been mentioned to have multiple or redundant organs.
Also, we've seen Hit in a tournament setting with no kill rules (Universe 6 vs Universe 7, Tournament of Power) and what he's like without such rules (when he was hired to kill Goku). Without rules, Hit went instantly for the kill when they engaged. The only reason he didn't kill Goku on the spot was because he respects him and didn't want to kill him. Even asking Goku to lay low.
Hit's assassin blast can be used close up or at distance. He demonstrates this when he fought Vegeta. Every time those purple lines come, that's Hit using the technique.
We know this because it was noted that Hit was attacking Vegeta internally. Vegeta called the attacks soft but as Hit was attacking his vitals, the damage was quickly adding up. Hit even tells him that he'll die if he keeps taking punishment like this. It should also be noted that Vegeta was more powerful than Hit.
Then, there's the fact that Hit can go intangible and make illusions/duplicates of himself. It's not very likely that Prime will ever actually strike the real Hit or even know where he's coming from. Additionally, Hit can improve in response to his opponent.
It's
possible for Prime to retcon punch Hit but it's almost a certainty that Hit will just one hit kill based on his M.O. and abilities. It's not a matter of if they could kill each other. It's about who could do that more often.
Prime has little to no control on his best bet to win, while Hit will use his from the start.
