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Depends on the medium. In most verses where you can destroy a soul, it usually results in insta-death. We don't have a specific function for it on this wiki.
Stands CAN affect souls, but they cannot affect souls if they are bound to a body. Star Platinum has never punched someone so hard that their soul broke, and there is no evidence or anything at all suggesting they can affect bounded souls.
That being said, Kenshiro would be considered a bounded soul, as in it's resided within his body. Him going Muso Tensei isn't enough because it's still bound to his non-existent body. Stands would need soul manipulation in order to reach it while he's alive in general. Once he passes away though it would be unbound, and any stand can touch it as it's just the same as any incorporeal.
Stands CAN affect souls, but they cannot affect souls if they are bound to a body. Star Platinum has never punched someone so hard that their soul broke, and there is no evidence or anything at all suggesting they can affect bounded souls.
That being said, Kenshiro would be considered a bounded soul, as in it's resided within his body. Him going Muso Tensei isn't enough because it's still bound to his non-existent body. Stands would need soul manipulation in order to reach it while he's alive in general. Once he passes away though it would be unbound, and any stand can touch it as it's just the same as any incorporeal.