It probably would since they are organic. Akame has shown to be able to take out all organic opponents with one slash, the only problem is that if they are machines or already dead or something along those lines.
Did you edit the thread? lol, well anyway
Akame would probably win round 1
I would probably say Tatsumi wins due to inviisbility and speed advantage for round 2
Mine was able to kill off budo, so if she keeps her distance she should be able to disintergrate gluttony for round 3
For Leone vs Lust, it's probably a harder match. I'd probably say that Leone since Lust got defeated by someone shooting fire, while Leone would probably have been able to dodge something like that.
Which greed are you reffering to exactly? Well actually tbh I think Lubbock and Bulat would win due to it being a two on one fight of similarly tier characters.
As for Sheele vs Envy, her scissors can cut through pretty much anyway, she could probably win if Envy doesn't manage to catch her offguard. Though Envy has Regenerationn, I'm not sure how well one he could regenerate after being cutting into really small pieces.
Susanoo would probably win due to speed and strength.
The sins have higher Regenerationn but they are still kind of humans to be honest. Akame ga kill characters can casually dodge bullets, and lightning giving them a huge speed advantage.
Even the fodder soldiers are probably faster than the average human by quite a bit which explains why they would use spears and swords instead of guns.