Yes, it's in character for DIO to job and toss out banter or insults, but once Zeno get mad enough to try erasing, either DIO will react the moment Zeno's hand starts to shine, or once he feels the sensation of the attack (the same one everyone being erased reacts too within the series, even if it's just them screaming, they can act for that split second while being erased), either way he'll stop time and override the effects of the erasure, then counter with a barrage of muda's until Zeno's erased within the stopped time.
And before someone says it, no, Zeno's erasure isn't instant, not once, across all of his uses of it has it been instantanious, there's a start up with him raising his hand and about a second for the target to fully vanish once the hand shine appears, assuming it's a single person, if it's multiple things, or a whole universe, it takes slightly longer, regardless, DIO's smart enough and can react quick enough to stop time before he's erased to counter.
