Makima scales above 381,348,643,100j due to scaling far higher than the Bat Devil who is that strong.
a HE Level Employee sould scale somewhat below, if not on par with, the likes of Meat Lanturn, which HE level employees can defeat. Considering that HE employees with high stats can still clash with WAWs 1 on 1, it's pretty reasonable to say they scale relative to them. Meat LAnturn and WAWs are I think 192,805,182,835.4589j
meaning Makima is 2 times stronger
if Makima gets in close there's nothing the Employee can do. Despite their max prudence stat, they still can't match Makima's age, experience, and martial prowess, and they'll get folded like an omelet in hand to hand.
Makima has several methods of hitting the Employee for RED damage, although due to several EGO Gifts granting resistances to all types of damage sans PALE, Makima will need a lot to take the Employee down despite her AP advantage. Without her contracts or Bang, she doesn't have much besides punching you in the face, mind control (which the Employee has layered resistance to), and Bio manipulation, which although the Employee doesn't have direct resistance to it, they can temporarily withstand the onslaught of Porcubus, who can cause employee's heads to explode after enough white damage, so it shouldn't instantly kill them
AP is barely a factor in this match from the Employee's side, as BLACK, WHITE, and PALE damage all bypass Makima's higher stats, and she has no resistance to any of it, especially BLACK and PALE damage, so if she gets hit a single time she'll take a lot more damage than normal. This is further exacerbated by Frost Splinter, which can actually slow Makima down every hit.
Not to mention, the Employee has several methods of outranging Makima with WHITE and BLACK damage, so getting in close isn't necessary
Before you say that Makima is skilled enough to dodge everything the Employee has, she can't dodge Syrinx, which is a sound-based WHITE damage attack, so she gets hit anyways with that