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He could simply create new ones, Madara could also steal chakra and even remove Isshiki's soul if he approached, or he would just use one of the limbs to do the job, since he cannot see or feel them, he would only have his soulVote for Isshiki,
while he may not resist stuff like IT and TSB's, he can still just flick them away into his dimension and can just rod Madara or just steal his chakra over time.
And even if Madara somehow manages to kill Isshiki which wouldn't happen, Isshiki can still Karma Seal and kill Madara over time
Not that much of a fight imo.
Yeah .. I had forgotten about that, due to the Karma seal, maybe it will become a stomp over time. I don't know if that would also work if he was just wiped out by the spheres or if he had his soul taken.