Natsu resists time stop, and Zeref specifically made Natsu/END to fight Zeref. This is why Natsu is able to resist time, death, and soul hax in verse. So given Zeref knows this, there was literally no reason for him to attempt time stop as it would have been useless.
Zeref also wasn't bloodlusted at all in their fight, as Zeref was intentionally holding back, and toying with Natsu so he could have a better fight and force Natsu to go all out.
Zeref resists powernull. And most of his stuff happens either on touch or by spawning it on Zagred anyways, which is faster than saying vanish or creating a spear. Zeref stomps here.