Uhh, well… I guess… For Sukuna and Yorozu, no; for Megumi and Tsumiki who are still in their bodies and presumably feel everything, yes.
Megumi and Tsumiki are step siblings, so there’s no inbreeding that would deter Sukuna and Yorozu (not like they’d care though, I guess), and even if there was, they could just incarnate and move along. Megumi and Tsumiki are still
step siblings though, so if killing Gojo wasn’t enough for Megumi to summon Big Raga to kill himself, this would.
Then again, Gege’s kinda had a sus track record with the Zenins. Depending on how you wanna read that scene, Tsumiki could be Megumi’s ideal type, and
in the databook they (Gege) said that either Maki (
) or Megumi was possibly Mai’s first love.