Ditto suffers most of all from not being Ditto. It can have Metal Powder or Quick Powder, which raise Durability or Speed... but only while it's a Ditto.
Does anyone know if Ditto keeps its IQ Skills while turned into a non-Pokemon like Lisa? IIRC, there is precedent for using IQ Skills on Pokemon pages. If so, Ditto's IQ Group is A:
https://bulbapedia.bulbagarden.net/wiki/IQ#IQ_groups Unfortunately, I'm unsure if many are very useful as or against Lisa, other than Item Master, since it would let it throw an item if it becomes useless.
How good is Ditto's capacity to copy Lisa's skill?
Then there's the matter of Stamina:
Stamina: High (Stamina is the only thing Ditto doesn't copy when transforming, Pokémon can remain in a fight for a long while)
Stamina: Very high. Lisa is capable of taking on multiple wrestlers without breaking a sweat.
(Suddenly, all those Pokedex entries some Pokemon have mentioning pro wrestlers feel oddly prescient now.)
Ditto also has two weaknesses: Being made to laugh & relaxing, both of which can cause it to undo its transformation. But if Lisa doesn't know about them, how likely is she to make her opponent laugh or relax?
So, uhhh, yeah.
I think this match depends on if Ditto as Lisa gets her skills, & if it still has its own IQ Skills, & maybe if it had any of its Standard Equipment.