Wokistan
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Dark Souls: Ressurection, and even the worst ones likely aren't as bad as the undead curse.
Magic: The Gathering: Not sure. This likely varies depending on the specific character. As for the Gatewatch, Liliana'd probably live but the others I can't see doing so well.
Bloodborne: Ressurection again, as well as non corporeality and reality warping later on. Maybe a plague inc disease kicked off the hunter's arrival to Yharnam, seeing as he was originally there for medical care.
Cthulhu Mythos: Don't the humans already have it hard enough
Darkest Dungeo: The Sanatarium's gonna be very busy, though the Sleeper and HoD should be OK due to their powers. If crimson curse was bad, this is likely way worse.
Destiny: lolno on hive and vex, and likely doesn't work on guardians either. Even if Guardians can die to it, resurrection. Looks like the Fallen aren't going to be around for much longer though, and the Cabal not named Callus are also probably in trouble.
Warhammer 40,000: See Azzy's comment
Salt and Sanctuary: Can plagues really affect a dude just made of salt? Ressurection, once again, is a thing.
Hotline Miami: Rip
Hollow Knight (Verse): In a way, this kinda already happens what with the whole Radiance thing. As such, the Hollow Knight(s) should be OK, but almost everybody else dies.
Super Smash Bros.: I am not going through this many characters tbh, off the top of my head Samus, ROB, and the tier 2s should be ok.
The Legend of Zelda: R e s s u r e c t i o n
DOOM: No idea how it interacts with demons, and several robots exist.
Magic: The Gathering: Not sure. This likely varies depending on the specific character. As for the Gatewatch, Liliana'd probably live but the others I can't see doing so well.
Bloodborne: Ressurection again, as well as non corporeality and reality warping later on. Maybe a plague inc disease kicked off the hunter's arrival to Yharnam, seeing as he was originally there for medical care.
Cthulhu Mythos: Don't the humans already have it hard enough
Darkest Dungeo: The Sanatarium's gonna be very busy, though the Sleeper and HoD should be OK due to their powers. If crimson curse was bad, this is likely way worse.
Destiny: lolno on hive and vex, and likely doesn't work on guardians either. Even if Guardians can die to it, resurrection. Looks like the Fallen aren't going to be around for much longer though, and the Cabal not named Callus are also probably in trouble.
Warhammer 40,000: See Azzy's comment
Salt and Sanctuary: Can plagues really affect a dude just made of salt? Ressurection, once again, is a thing.
Hotline Miami: Rip
Hollow Knight (Verse): In a way, this kinda already happens what with the whole Radiance thing. As such, the Hollow Knight(s) should be OK, but almost everybody else dies.
Super Smash Bros.: I am not going through this many characters tbh, off the top of my head Samus, ROB, and the tier 2s should be ok.
The Legend of Zelda: R e s s u r e c t i o n
DOOM: No idea how it interacts with demons, and several robots exist.