Okay so to start,
Junko (ignore how trash her profile is) has type 2 NEP as nameless beings in Touhou exist without the boundaries of existence, nonexistence [zero], and void [imaginary number], which by extension includes
all boundaries, making them unbound from the dual system of the entire verse. On top of being untouchable, Junko's main technique is "purifying" people by removing their names (type 1 concept), and it is in character for her to do this. So afaik, nobody in 2-C can even touch her, and the lower tiers would just die instantly to concept EE. This isn't even counting the void/RW/mind/empathic/probability/causality/fate/physics hax nameless gods have.
Yukari has type 1 CM over a multiversal range, which includes abilities like matter/antimatter manip, life/death manip (which negs type 5 immortality and MGR/HGR), BFR, conceptual EE (which can erase nonexistence), dimensional manipulation, sleep manipulation, and vector manipulation to name a few. This is excluding her other powers like power null, telepathy, mathematics manipulation, sealing, immersion, dura neg, and youkai physiology (which grants incorporeality, passive fear hax/spirit absorption, and so on). She also resists shit like power null, power mimicry, death hax, layered mind hax, subjective reality, and transmutation.
Reimu has thought-based spatial intangibility on a 2-B scale, passive layered probability/fate hax that make her untouchable and tilt victory in her favor, power null on touch, thought based summoning which includes type 1 CM (which Reimu can also do in base), death hax, and illusions, BFR, regen negation up to mid-godly, and transmutation.
All of these characters can interact with abstract ideas like divine spirits, as well as regular incorporeal beings made of souls and such.
As an aside, other Touhou characters have their own busted stuff, like Yuuma having passive power absorption or Yuyuko having passive death hax, but idk if that'd be enough to get a spot.
TL;DR: yeah they can probably beat someone like yubel idk