Considering how Goku is over 5 times stronger (Goku actually scales to
over 177.6 Exatons, not 117) , a few years older, and has had MUCH higher quality martial arts training, Goku can either go for the knockout, or just blatantly outskill her even after she buffs herself. All else fails, Super Kamehameha can disintegrate people far beyond his level, as demonstrated by Beginning of Z Goku, who's ordinary Kamehameha made his power level go from 416 to 924, which means it can potentially double his AP.
Ryuko needs to go out of her way to force Goku to kill her in order to abuse her Accelerated Development, as she basically has Saiyan Zenkais + Regeneration, which would be OP if not for the fact that Goku wouldn't kill her in character. Ragyo had to stab holes in Ryuko's body hundreds if not thousands of times over for Ryuko to reach her level, while Goku would likely just be overpowering her with punches, or, like I said earler, knock her out cold immediately cuz she's fodder