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It's gonna be hard as hell, if not impossible to put down the TF2 members as long as Medic is still alive, as he can help people regen from this. And Medic is almost always the last one standing in a fight with the rest of the crew, and Team TF2 keeps protecting him their number one priority. If being caught of guard is a weakness for Reaper, then Spy can handle him. He can disguise himself as a member of Team Overwatch and finish Reaper off while he's not paying attention, and can absorb his health. Saxton Hale has minor toon force, so he could probably get past that intangibility, and Merasmus does have magic and transmutation.