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^Toxics/nerves are no problem for gourmet cells imo, they have reactive evolution for biological thingys. Gremmy's abilitie is limited by the difference in power of the two combatants, he lost because zaraki was too much for him to handle (a PIS weakness, yet, a weakness) and also putting Midora in galaxy room would be really difficult imo, he has escaped the can trick befre it was completed, so i doubt he would fall for that. About the blood... well...he could always cut any affected part and regenerate it, or simply destroy it just lile he did with the bacteria (joie's)... X-Axis hasnt shown AoE enough to be a problem, he can regenerate just fine. Note that Yhwach needs to finish really quickly the fight because the longer it takes the more ailities will midora copy.