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First of all, Anos and every other person were not "unaffected" by the Sun of Destruction. The Sun of Destruction simply decided that only Avos was supposed to be destroyed. Just read the epilogue of the arc. As for the gun analogy such as shotguns vs sniper rifles, it seems like a good example to me. I don't remember a time when sniper rifles shot shotgun shells, so they're definitely not the same bullet. Here's some proof that "reason destruction" comes from Anos twisting the order of destruction.
Clearly they're different. Stop saying they have the same powers. I thought this was obvious."When that vessel is filled with your source and your divine body, a magical contract will be made with me. I will twist the order of the God of Destruction and turn the Sun of Destruction <Sarge El Donave> into the magic that destroys reason, the sword of reason destruction <Venuzdonoa>. With that, the order of destruction that you possess will be completely taken away from this world."
- Chapter 396 of the Web Novel