Nah, both Sasuke and Naruto (together) are slightly stronger than Madara, while Kaguya stomped them both, Kaguya lost because of Naruto kept outsmarted her (Itachi/Kakashi/Kabuto's level of intelligence is necessary to see through Naruto's unorthodox strategy anyway lol), underestimated Kamui's hax power and forgot about the useless Sakura (and possibly backed with
Plot-Induced_Stupidity) might do something on her blindspot
Limbo Hengoku is useless against her, she has Rinne-Sharingan, and I think even her Byakugan should be capable to see the invisible shadow clones
Her taijutsu / ninjutsu were also above both Naruto and Sasuke, Sasuke's Perfect Susanoo destroyed with a single chakra ***** slap, even reacted to the Sasuke's Amenotejikara
her Kekkei Mora Byakugan + Rinne Sharingan > Rinnegan + Rinne Sharingan, whose quality should be lower than the original owner, Kaguya herself (better sensing ability)
Kaguya also has All-Killing Ash Bone, turn anything into ashes, easily pierced Perfect Susanoo's armor, even Naruto's miraculous Jesus-like healing ability can't stop its effect
on top of all, she has ETSB
Madara's only chance to win is only through trickery, as she is just a lonely woman :'D, he could just propose a marriage to her and then seal her for good later xD
Kaguya +1