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If he has a heart and is alive (i.e his heart beats), Murasame will kill him. There's no indication it spreads through the blood. If anything, the manga shows it spreads through the curse markings that appear on the wound.

On average, a blood cell needs ~1 minute to make a round trip to the heart. If we assume half of that time (since Esdeath was sliced on her arm therefore the time it would take the blood from her arm to her heart would be shorter), that gives us ~30 seconds. Since she was fighting, her blood flow would normally be faster, so assume half of that time, meaning 15 seconds.

With 15 seconds to spare (which is a lot considering Esdeath's speed) she wouldn't really need to use such an exhausting move like Mahapadma to slice her arm off.

Another proof is Akame slicing fodders with Murasame and the curse activating almost immediately after being cut.

This is why when you're bitten by a venomous snake it needs a while for you to feel the effects of the venom and it is advised you do not move around to much because the venom spreads faster that way.

So the curse doesn't travel through the blood.
 
Also there are votes here that mention Asgore's speed advantage. He's MHS+ (At least Mach 1000+) while Akame is MHS (~Mach 300 iirc). That's enough of a speed advantage to blitz her.

I'm gonna have to either close the thread and remake it, or invalidate votes mentioning speed. And I really prefer the former.
 
Anonimoe7875 said:
Asgore is at least Mach 3000+...
I don't know his actual value, I just used the lowest value of the MHS+ tier. But the actual value makes this even more of a blitz -_-
 
The votes above are either via speed, or thinking her poison won't affect him.

I'm pretty sure if we're going to continue we make a rematch
 
Yes, everyone else simply said "Asgore for reasons above" because Akame hax wouldn't work agaisn't him... and due to his soul manipulation
 
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