Alright so looking at their stats given that they both need to amp themselves into their Low 5-B forms:
Uryu 5-C: 116.8344 Exatons
Uryu Low 5-B: 1.1683 Zettatons
vs
Zoro 5-C: 188.362 Exatons
Zoro Low 5-B: 3.014 Zettatons
So Zoro is always going to hold a slight AP advantage in these keys, but Uryu has range and can get him that way, especially with a well timed The Antithesis. That said, Uryu's amp with Blut Arterie poses far more risk for himself and is more committal vs Zoro simply using his Armament Haki, moreover Zoro upscales from his values with his stronger attacks so he does have the tools needed to oneshot Uryu. He also does have DuraNeg he can fall back on, so he won't really have a problem taking down Uryu if he uses Blut Vene, though that'd mean that Zoro is then punching way above Uryu's weight class.
Speed is equalized here so neither get an advantage there, Hirenkyaku could potentially give Uryu an edge speedwise (it just makes him vaguely
faster), but Zoro kinda sweeps all other options due to his Observation Haki. Uryu doesn't really have a counter to Zoro just reading all his moves, especially when Zoro is the more skilled combatant. This kinda directly counters The Antithesis too, because Zoro would know that Uryu could just do some unknown insta-kill move on him if he doesn't take him out in one shot, meaning he would then go all out to take Uryu down in one go.
And as also mentioned prior in the thread, Zoro could do a Conquerors Haki wave (though it's not something he's done before), Uryu is strong willed but he's never shown a specific resistance to Willpower Manip like that
Voting Zoro
