Hello, I wish to participate in this discussion, hope we would have a good debate.
I would be making an analysis of who has the most advantages. I do have more knowledge of the MHA franchise, while I haven't fully watch MegaMind, I had seen a few videos to at least know enough on TIghten fighting capabilities.
Attack Potency
While both AP are comparable, with Tighten having a slight edge by 0.556 tons. How they deliver it is quite different. Bakugo is his explosions, while for Tighten is him throwing the half skyscraper. I would go with Bakugou since his way of delivering his strikes is more focused and consistent while Tighten requires an external mass not his own to create the force(with a help of gravity too). I doubt his punch would be delivered as strong. It would be like throwing a heavy rock against a wall and claiming your punch can do the same. Though with the selected battlefield, Tighten does have significant Ammo for it.
Bakugou gauntlet could have a leg up by storing his gauntlet for a more explosive generation.
Speed and Mobility
Speed is equal and neither had significant speed amplification save for maybe Bakugou which is more of a burst. So Mobility would be relevant. And Tighten had the advantage for having a "true" flight, while Bakugou is more on propulsion.
Abilities and Power
They both have very distinct abilities, with Bakugou having more utility with his Quirk and Support Item and super moves like the Stun grenade and actual grenades, while Tighten is more versatile with his flight and laser beams that have greater range.
Intelligence and Skill
Bakugo has the greater intelligence and skill of the two, being a top student in a top school, having good grades. Despite having short temper and extremely prideful, is still a hard worker and has a good understanding of his Quirk and tries creatively to create new super moves. And he has shown to be able to do good deduction such as discovering the weakness of a villain despite just one meeting. Plus he has actual combat training
While Tighten is stated to have less common sense(in the VS wiki), and easily affected by emotions, and unlike Bakugo, haven't shown to have a good instinct in battle. While he did manage to figure out that the "Metroman" he had met was Megamind by the latter tendency to call Metro City "Metrosity". I am not sure if that is a really good deduction since it's the knowledge that has already been known and can probably be considered common. Megamind and Metroman had fought dozen of times, and the two of them does not define subtlety. And his training isn't really that effective of giving him actual combat skills.
Though I think the most important factor is combat experience. And Bakugo has fought someone who is equal to him in power and even greater, showing good reflex and tactics despite his everpresent anger. While Tighten is emotional as Bakugo, that's all he ever is, only fought Megamind who as we know never really do wish to harm anybody and more or less expect to lose since that is usually how it goes(heroes beat villains), and being outsmarted by Megamind all the time, only powering through his tricks through brute force rather than skill.
Location
While Bakugo does have familiarity with Ground Beta. I am not sure if it is truly a major advantage since it is just a simulation of a generic urban city, something both Bakugo and Tighten would already be familiar with. Though the former might actually use it either as a cover of his laser or to lure him in a trap, I am not sure if Tigten would do anything else other than throwing debris.
Conclusion
How I think would go in my opinion. Is that the two would clash at close combat(I doubt Tighten would have reason to simply fly away from someone that he doesn't know), Bakugo realizing that his opponent could fly and shoot lasers later on, would come up with something to make pummeling the flying idiot(I would assume that would be Bakugo thought process on Tighten) easier. Stun grenade would be his major arsenal due to the fact that it could blind him and prevent him from using his heat vision momentarily. And with Tighten being temporarily immobilized, Bakugo would take the chance to take him using his Super moves or maybe his gauntlet to take Tighten out.
So my vote would be Katsuki Bakugo, due to having the ability that could counter Tighten's, having the skill and combat experience to outsmart Tighten who had never shown any relevant combat skills.