Well...
Depending on what they're capable of, he could potentially find the connection between her and the gods backing her and cut that off. Given what he's capable of, it's definitely not a stretch to say that he could do that, especially since he's done similar things like finding the connection between the Lamentation and its army and then severing that. And ripping out a higher-dimensional "taint" that had directly fused with Kid Cthulhu.
As for BFR, well, he's capable of reaching all the way into the setting's afterlife and affecting things in it with his powers, and said afterlife is confirmed at least once to be a higher space above every dimension in the setting. We don't know how many dimensions there are (yet), but it's...a lot. He could possibly BFR Lucetta past the point of coming back (unless her dimensional resistance is downright absurd), or send her gods packing to a higher or lower dimension as well.
There's also his ability to...well, just read this:
from Something From the Nightside |
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The nothing was replaced by something. An in-between place. I was standing on a bare plain that stretched out to infinity in all directions. It was a grey place, soft and hazy and indistinct. Not a real place, but real enough. A place to make a stand. Suzie and Cathy were there with me. Suzie was wearing silver armour, studded with vicious spikes. Cathy looked like she had in her old photo, only mad as hell now. I didn't look down to see how I appeared. It didn't matter. Not too far away there was another presence, too faint to be clearly seen, but I knew who it was. Who it had to be. We were all shining brightly now, luminous beings in a grey world. Together we formed a wide circle around a column of swirling darkness, shot with vivid blood-red traces, that towered endlessly up into the featureless sky. From it came the voice of the house, beating against us like hammer-blows, harsh and inhuman.
"Mine! Mine! Mine!"
But the gift was strong in me, and I just laughed at the voice. All it really had on its side was stealth and lies, and neither could serve the house here. I stepped forward, and Suzie and Cathy moved with me. The dark column actually shrank back from our light, shrinking and contracting away from us. We closed in, and the column became narrower. And all around us, on that wide and endless plain; hundreds and hundreds of insubstantial figures, standing silently, watching and hoping. All the house's victims. It hadn't just eaten their bodies; the damned thing had consumed their souls too, holding them within itself to power its unnatural existence. What was left of a woman called Joanna came forward, holding herself together despite everything the house could do to tear her apart and assimilate her, and again I felt her hand in mine. Through her I reached out to the other captive shades, silently offering them a chance for revenge, and the only freedom they could ever know now ... and they reached out to me.
Power surged through me, igniting my gift, and I blazed so very brightly as I advanced on the dark column before me. Suzie and Cathy and all the other victims advanced with me, and the house screamed and screamed. The column shrank and compacted, growing thinner and thinner, until finally I was able to join my shining hands with the trusting Suzie, the furious and betrayed Cathy, and the ghost of a woman I could have loved. We were all shining like suns now. I gathered together all our rage and hate and need, channeling all the many victims through my gift, and struck out at the dark heart of the thing that pretended to be a house. It howled once, with impotent horror, and then the dark swirling column was suddenly gone, and the voice of the house was stilled forever.
The other side of my gift. To find another's death.
I've never carried a gun. I don't need one.
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also from Something From the Nightside |
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"Where were we?" she said abruptly. "The grey place. What was that?"
"The house was only vulnerable through its heart," I said, urging her towards the place in the wall where the door had been. "So, the house hid its heart in another place. Another dimension of reality, if you like. It's an old magical trick. But I can find anything."
"Are you sure it's dead?" said Suzie. "All the way, not coming back in the last reel, dead? I mean, it's still here, and we're still trapped inside it."
"It's dead," I said. "And from the smell and general state of things, I'd say its body is already starting to decay. It never really belonged in our world. Only its augmented will allowed it to survive here."
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He doesn't have the benefit of having hundreds of disembodied souls to amp him even further here, but he doesn't really need it if Lucetta and the gods backing her aren't above 3-D. He did this against an
Outsider (read: an immaterial, extradimensional cosmic horror), and those things are regularly treated as being extremely difficult to put down by normal means, even if you have something that can actually hurt them. Doing it against a 3-D being, even without the souls amping him, shouldn't be particularly difficult.
EDIT: This also happened after he'd been weakened to an absolutely massive degree thanks to overuse of his gift. Take that however you will.