Basically yes. A more significant change will be harder for the Divine Armour to negate, and a change to the whole body is way more significant than just having the heart stabbed.
As for their Regenerationn, Restoration is only as good as the willpower of its user. Sure it will let them regenerate from basically everything, but only if they don't Zeroth first, which in most cases is a lot more likely than not. Not all Hallows can actually regenerate more than low-mid. A lot of them would Zeroth if you made their brains explode because they don't have enough will to keep themselves around after the shock of their brains exploding. Same with messing with their concept, matter, mind, soul (sometimes).
Plus Alaya is actively supressing all their powers as long as they are within Percieved Reality / Recorded Events, meaning they can only enact their abilities within a few milimetres of their skin, so they need contact to use them, with the exception of Alexander, and that's only because his power is actually working with Alaya rather than against it. And for the majority of the series, his power is more of a liability than a benefit, because he can't control it properly and negates the powers of everyone around him, including his own teammates.
To the majority of beings in my verse, Hallows are basically those monsters from horror video games that chases after you, can be held back by attacks but will come back, and if they reach you they will kill you.
There's also the Magicians, which is just anyone who uses any form of magic. An important difference between Divine Influence and magic is that magic is considered by Alaya to be something that could exist, while Divine Influence is something it refuses to allow anything else to do, and so is rejected by it. So Magicians can freely use their abilities without restriction, meaning that they overall have more AP in comparison to a Hallow of comparable level, but they tend to be glass canons.