Looking at his resistance it kinda reminds me of this
guy, he poisoned Gohan and to avoid his poison in the ToP arc (proper) Goku and Vegeta didn't actually resist the poison but blocked the medium of getting poisoned with a ki aura around their bodies (similar to how Future Trunks deflected Dabura's stone spit), I dunno this seems a little dubious but that's for another discussion.
So what's Future Trunks win-con? AP is pointless since both get rapidly stronger overtime and Trunks can't bypass Bills regen normally requiring him to rely on a specific technique, that takes time to charge and actually has to hit the target too. Yeah I don't think Sword of Hope is a real win-con, it all depends how long Bill plays around before doing something actually game ending and if Trunks can doing something before then.