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Pure Demons doesn't have a statement of being tired... Weakened, yes. Sparda inflict a wound that even Beowulf couldn't Regen, Bolverk had a scar in the past prior fighting weakened Sparda. Mundus still having so much power to kill Dante in DMC 1, but dude is weakened and his regeneration got slow because Dante using his father power. If it does tied to stamina then Vergil would've been sliced in two at the end of DMC 3.demons struggling to regenerate are regeneration negation when they are just evidence that their regeneration is just linked to their stamina
Sid with Abigail power show that he could regenerate from puddle of blood, yet Dante destroy him completely without him being tired or having stamina issue.