Well this is a weird fight. Also enderman having prior knowledge? I mean, ok, its allowed, but are endermen actually smart enough to understand said knowledge?
So going into the fight itself, there's a lot of factors to consider. Since pre-multiple colliders Spot is used, its likely that in this key he's not skilled in using his powers, while the enderman knows how to use their abilities, so points to Enderman there. That being said, Spot may be inexperienced, but not dumb, so I could probably see him learning how to use his powers overtime given that he was able to do so after a few days of universe hopping.
In terms of abilities and weaknesses however, Spot probably takes this more often than not. While the enderman can teleport and travel between dimensions, Spot can do this but on a much bigger scale, being able to hop between multiple universes relatively quickly while the enderman can hop between 3. Not to mention that Spots teleportation outdoes the Enderman's by being able to BFR people to different universes or areas. I mean, the Enderman can probably do it to, but even if they could its not in character for them to do so. Plus Spot can resist BFR himself cause of... well...portals.
In terms of physical capabilities, Enderman is stronger, but since Spot can keep up with Spiderman's Spider Sense, he technically takes this in terms of speed even though speed is equalized here, and the AP differences isnt all that big either.
The biggest factor though that gives Spot the win is simply the Enderman's weakness... which is water. Granted, the fight does start in the end, but given that Spot would most likely want to bring the fight to his home area (not to mention the End is scary af to a normal person), I could probably see them moving to a universe where Spot realises Enderman's weakness to water. Not to mention sunlight makes the enderman more passive, so even if they dont jump to a universe where there is water, Spot could likely get the advantage fighting in a bright area.
So yeah I think Spot wins. Ap diff isnt all that big and Spot can keep up with precog users, and Enderman has weaknesses which Spot could exploit if he uses portals, which he could since he's inexperienced, not dumb. I vote Spot.