@J-Man - as she's lifting the debris, Doflamingo can jump downwards back to the surface with Sora no Michi attached to the pieces of city being thrown up into the air, or he can convert all of it into threads and control it at will. Speed is equalized, and hypersonic speeds aren't even impressive.
@PaChi - I know she tends to do that, but that's suggesting Doflamingo stands there, let's tatsumaki attack first, and display absolutely no resistance against her. He has pre-cog where-as she doesn't. If anything, He will make the first move, which could throw Tatsu off, especially if Doflamingo uses Awakening out of fear for the glimpse of his potential death that he sees.
I noted that Tatsumaki has the initial advantage, and that's the most opportune time for her to be successful in this fight, but she could also fall victim to Doflamingo's threads, especially if she doesn't notice them at first while she's squishing his body. She did fall prey to her own weakness due to one of her opponents sneaking up and landing a strike on her head. "When a psychic becomes focused on attack, their defense becomes frail". When Tatsumaki is busy attempting to kill Doflamingo, he could simultaneously be attacking her with a blind-siding attack such as Full-Bright, Parasito, or an awakening attack.
When Tatsumaki was focusing her attention on the Monster Association, Psychos snuck up on her and took advantage of her lack of active defense and easily landed a strike on her, which crippled her for the rest of the fight. Am I wrong in assuming that Doflamingo could do the same with an ability that was introduced as being subtle/invisible to the opponent's eyes?