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As you may know the new Isaac DLC came out recently, so i wanted to add some stuff that is missing from the Afterbirth+ exclusive Isaac and verse in general. For this thread i will divulge into the meta aspect of Isaac for a tier, though that will be discussed the last, so for now some powers
Intangibillity via Dark Arts
Existence Erasure via Eraser (Interstingly enough bosses and enemies will remain erased even after using the "R" Key item) it also has a property where things that are erased cannot appear again so for example if i erase a fly and there is an enemy that spawns flies, he is unable to do so after i did it
Creation? via Red Key (It allows creating "new rooms" in already small floors)
Can slow down and weaken enemies via upside down Strength
Upside down Magician provides greater projectile repelling aura than the Soul
Supernatural Luck should be added from various luck boosting items, though luck also has a large part in tear effects and the like. Also Cain's Lucky Foot which converts normally bad pills into good or neutral ones, but also increasing the chance at winning in stuff like slot machines. Sacred Orb also prevents lower quality items to spawn
Soul Manipulation from Vade Retro (Allows Isaac to destroy the ghosts enemies leave behind after death), Hungry Soul (Which lets Isaac use the enemies ghosts after death to attack other enemies), also passively summons spirits from Purgatory
X-Ray vision? from Guppy's Eye, it allows him to see if and what chests, fires and sacks have inside them
Passive empathic and fear manipulation from Venus and 2Spooky
Ice Manipulation from Uranus (Currently he has it incorrectly on his profile, Mom's Contact petrifies enemies not freeze them)
I'm not aware of what Echo Chamber fits to, Power Mimicry maybe?
R Key is also weird, it makes it so Isaac keeps everything he has but resets the run to the first floor allowing him to potentially fight the same final bosses multiple times, also has interesting interactions with Eraser as said above, the timer does not reset though
Full Earth Manipulation from stuff like upside down The Tower and Terra, also Inorganic physiology for the latter since he is literally made of rock.
Gravity Manipulation from Ocular Rift, Tiny Planet, Saturnus etc. generally he can make his tears orbit himself with the latter and attract tears, enemies, pickups etc. with the former
Precognition Dream Catcher which shows Isaac future bosses and items
Attack Reflection from Divine Intervention
Resistance to poison and fear with Evil Charm
Power Nullification in this case projectiles as he can negate them with Lost contact and fire abillities gained like Ghost Pepper, Bird's Eye, Candles etc. passively aswell via Broken Modem, this was added in Repentance
Non Physical interaction tons of enemies are ghosts or spirits, which Isaac can harm, but also weird abstracts like Delirium and now Dogma (I'm amazed it wasn't on there)
Sound Manipulation via Larynx
Resistance to Soul Manipulation, Isaac being able to control his soul is nothing new, but Astral Projection the actual item negates a hit of damage and returns his soul back. Also "Soul" disembodying items interact with extra lives, as in, even if his soul may be defeated he can seemingly rebuild his body and soul again
Mind Manipulation? from Rotten Tomato
Spindown Dice rolls down an items internal value, if the value would be the lowest in the data it makes it disappear instead
Tainted Apollyon is also an oddity since he is shown to be comprised of the "abyss" or a void portal of sorts, the item he has looks like his cracked head and essentially destroys items to gain new locusts. Same for T.Eden who is shown in the posted note to be a glitch entity
EDIT: I've found more stuff to add
Regeneration upgrade, various items make Isaac lose body parts, for example The Intruder completely destroys his head and Isaac regrows it when going out of a room, this should make it Mid level regen
Berserk Mode via Berserk!
Resistance to Disease manipulation, Isaac can hold Cancer and is completely fine, but also various other infectious or disease items like Leprosy
The Mind and other map/place revealing items should give him Clairvoyance
Panic Button lets Isaac use an active item before he would take damage, this would trigger shields, teleports and other items to protect him and evade attacks. Instinctive reaction seems to be the only thing that fits this from what i gather
Extrasensory perception, from various items that limit his eye sight or the above like him literally losing his head, that is to say he can function fine even with just his lower half
Probability manipulation from various items that prevent him from getting bad or unwanted outcomes for example Eucharist and Goathead, basically there is a percentage chance if Isaac gets angel/devil rooms, but those items guarantee that they appear. I've also mentioned Sacred Orb which prevents lower quality items from spawning, he can also pick between 2 outcomes from the "Option" items. But this goes alot deeper with percentage chance items and stuff that gives him better odds at getting different things, probably alot more than i can name of the top of my head
Limited Spatial Manipulation from Continuum, which allows his tears to go beyond rooms, come back and loop around
Resistance to Ice Manipulation, from Uranus wherein he is frozen or made of ice and once again is able to function as if nothing happens and Electricity manipulation where his head emits constant electric sparks from Jacob's Ladder, Reality Warping from Missing No which glitches his body up before turning back to normal, Blood Manipulation (Red Hearts in Isaac function akin to blood) Sumptorium further makes this point clear via the Blood Clots but also various blood disease items like Vasculitis or Haemolacria
Fate Manipulation/Plot Manipulation. So the game emphasizes routes and endings as different paths of Isaac's subconscious and imagination evidenced by the Polaroid/Negative which say "Fate Chosen" as their description. Though a more literal example he has control over the story as he literally changed the ending of ending 22 from a more grim ending where he sees a better alternate path flashing before his eyes when he ascends after defeating the Beast (Which is another embodiment of his Mother) to a more happy ending when his father recommended it to which he agreed.
Powers and Abillities
Metal manipulation via Anima ZolaIntangibillity via Dark Arts
Existence Erasure via Eraser (Interstingly enough bosses and enemies will remain erased even after using the "R" Key item) it also has a property where things that are erased cannot appear again so for example if i erase a fly and there is an enemy that spawns flies, he is unable to do so after i did it
Creation? via Red Key (It allows creating "new rooms" in already small floors)
Can slow down and weaken enemies via upside down Strength
Upside down Magician provides greater projectile repelling aura than the Soul
Supernatural Luck should be added from various luck boosting items, though luck also has a large part in tear effects and the like. Also Cain's Lucky Foot which converts normally bad pills into good or neutral ones, but also increasing the chance at winning in stuff like slot machines. Sacred Orb also prevents lower quality items to spawn
Soul Manipulation from Vade Retro (Allows Isaac to destroy the ghosts enemies leave behind after death), Hungry Soul (Which lets Isaac use the enemies ghosts after death to attack other enemies), also passively summons spirits from Purgatory
X-Ray vision? from Guppy's Eye, it allows him to see if and what chests, fires and sacks have inside them
Passive empathic and fear manipulation from Venus and 2Spooky
Ice Manipulation from Uranus (Currently he has it incorrectly on his profile, Mom's Contact petrifies enemies not freeze them)
I'm not aware of what Echo Chamber fits to, Power Mimicry maybe?
R Key is also weird, it makes it so Isaac keeps everything he has but resets the run to the first floor allowing him to potentially fight the same final bosses multiple times, also has interesting interactions with Eraser as said above, the timer does not reset though
Full Earth Manipulation from stuff like upside down The Tower and Terra, also Inorganic physiology for the latter since he is literally made of rock.
Gravity Manipulation from Ocular Rift, Tiny Planet, Saturnus etc. generally he can make his tears orbit himself with the latter and attract tears, enemies, pickups etc. with the former
Precognition Dream Catcher which shows Isaac future bosses and items
Attack Reflection from Divine Intervention
Resistance to poison and fear with Evil Charm
Power Nullification in this case projectiles as he can negate them with Lost contact and fire abillities gained like Ghost Pepper, Bird's Eye, Candles etc. passively aswell via Broken Modem, this was added in Repentance
Non Physical interaction tons of enemies are ghosts or spirits, which Isaac can harm, but also weird abstracts like Delirium and now Dogma (I'm amazed it wasn't on there)
Sound Manipulation via Larynx
Resistance to Soul Manipulation, Isaac being able to control his soul is nothing new, but Astral Projection the actual item negates a hit of damage and returns his soul back. Also "Soul" disembodying items interact with extra lives, as in, even if his soul may be defeated he can seemingly rebuild his body and soul again
Mind Manipulation? from Rotten Tomato
Spindown Dice rolls down an items internal value, if the value would be the lowest in the data it makes it disappear instead
Tainted Apollyon is also an oddity since he is shown to be comprised of the "abyss" or a void portal of sorts, the item he has looks like his cracked head and essentially destroys items to gain new locusts. Same for T.Eden who is shown in the posted note to be a glitch entity
EDIT: I've found more stuff to add
Regeneration upgrade, various items make Isaac lose body parts, for example The Intruder completely destroys his head and Isaac regrows it when going out of a room, this should make it Mid level regen
Berserk Mode via Berserk!
Resistance to Disease manipulation, Isaac can hold Cancer and is completely fine, but also various other infectious or disease items like Leprosy
The Mind and other map/place revealing items should give him Clairvoyance
Panic Button lets Isaac use an active item before he would take damage, this would trigger shields, teleports and other items to protect him and evade attacks. Instinctive reaction seems to be the only thing that fits this from what i gather
Extrasensory perception, from various items that limit his eye sight or the above like him literally losing his head, that is to say he can function fine even with just his lower half
Probability manipulation from various items that prevent him from getting bad or unwanted outcomes for example Eucharist and Goathead, basically there is a percentage chance if Isaac gets angel/devil rooms, but those items guarantee that they appear. I've also mentioned Sacred Orb which prevents lower quality items from spawning, he can also pick between 2 outcomes from the "Option" items. But this goes alot deeper with percentage chance items and stuff that gives him better odds at getting different things, probably alot more than i can name of the top of my head
Limited Spatial Manipulation from Continuum, which allows his tears to go beyond rooms, come back and loop around
Resistance to Ice Manipulation, from Uranus wherein he is frozen or made of ice and once again is able to function as if nothing happens and Electricity manipulation where his head emits constant electric sparks from Jacob's Ladder, Reality Warping from Missing No which glitches his body up before turning back to normal, Blood Manipulation (Red Hearts in Isaac function akin to blood) Sumptorium further makes this point clear via the Blood Clots but also various blood disease items like Vasculitis or Haemolacria
Fate Manipulation/Plot Manipulation. So the game emphasizes routes and endings as different paths of Isaac's subconscious and imagination evidenced by the Polaroid/Negative which say "Fate Chosen" as their description. Though a more literal example he has control over the story as he literally changed the ending of ending 22 from a more grim ending where he sees a better alternate path flashing before his eyes when he ascends after defeating the Beast (Which is another embodiment of his Mother) to a more happy ending when his father recommended it to which he agreed.
Enemies and other profiles
Enemies, bosses etc. are all figments of isaac's imagination, they can die and be recreated repeatedly through runs, final bosses especially you can fight multiple times through Victory laps and R key. So i think immortality type 8 should be on their profiles, Delirium especially should get abstract existence due to literally being an embodiment of Isaac's delusionTiering
EDIT: Currently the Isaac cosmology is Universe sized at the very least, the planetarium rooms and posted notes confirm this, though i've decided to keep this for a later time when i have better justification for them if i even get the chance, so sadly i've omitted my original comment due to some inexperience in how Reality/Fiction works, sorry again
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