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Phazon mutations are basically just temporary increases caused by the body's reaction to the alien substance. Phazon does seem to attempt to look for hosts, but seems unable to find one without outside help due to how it inadvertently destroys the body. The Space Pirates are basically just able to successfully merge the host with the Phazon, at the cost of what the host once was...and the fact that an imbalance in the substance could still result in their death.
There's also the explanation of it being sci-fi and them just not caring enough about actual science.
There's also the explanation of it being sci-fi and them just not caring enough about actual science.