So, looking at the profiles, Deku is at his peak is 2.54 Exatons whilst Kafka is 646 Petatons, so nearly 4x, and that difference can severely increase due to Deku’s other quirk up to 5x and more. However, Kafka can steadily reduce the difference as time passes.
However, as speed is not equalized, the speed difference is insane as Kafka it is around 13x iirc comparing Deku’s 62.27% SoL to Kafka’s 8.47c, so Deku is really, really going to struggle tagging Kafka, especially when he is going to get faster and faster.
In this key, Kafka is just going to continuously regenerate infinitely unless Deku destroy his core, which is surrounded by a pretty sturdy forcefield, but landing it is going to hard as already mention before. So Kafka can outlast him pretty severely. Iirc, Deku has trouble with Shigaraki’s Regeneration, which is lower than Kafka’s, unless Deku is going with the Soul Manipulation route of transferring One for All to Kafka, which I don’t really know if he would as Kafka is not trying to destroy everything like Shigaraki is.
There is the matter of Deku handling Kafka’s
Daikaiju aura and
Incorporeality. Deku does have his Danger Sense and Analytical Prediction, but Kafka has spent months training with
Gen Narumi in his Numbers Weapons without receiving any noticeable damage despite Gen’s suit has countless RT-0001s with each one being able to predict a person’s movement before they even budge by analyzing their body electrical signals to perform attacks that is undetectable to automatic attacks and defenses and consistently stated to be inescapable, but also see the literal future, hundreds of future simultaneously in fact.