I usually root for everything not-regular-human to wreck humanity in fiction because irl humanity sucks and whenever the humanity isn't based in it like Ordem Paranormal, Hunter x Hunter or other similar titles, it is way more racist and ridiculous in general like Skyrim and specially Warhammer (from the very little i've read so far, the Imperium of Mankind SUCKS ASS, everything is heresy and they wipe the brains of otherwise regular humans just to be a cyborg to open a door or a baby with wings to carry bullets/rounds).
Gets a bonus point with me if what's destroying mankind is part of the nature of the world or universe, like Warhammer's Chaos (Cruel too? Yeah, a lot. But humankind is doing a lot of f***** up things and Chaos was already there before them, so i'm at neither side, but i'm 100% more at Horus' side than the Emperor's) or Ordem Paranormal's Holy Cradle (the Other Side elements were already there, some guys just put this medieval community from Iceland in Brazil in 2019 and like 6 guys suffer inside a white room to get a whole community to be fine? Yeah, i want to kill Ferreiro too, but the rest is not as horrible, ngl)