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Luffy outranges but they're starting 10 meters away so Foxy can attack him with Meteor Rain or the Bi-plane to buy time, even if Meteor Rain shouldn't be hard to avoid. He could reasonably get in with his 5 uses of Meteor Rain and his Shield powerup + slides though.
Hard to say who's more intelligent when it comes to battle since we know nothing about Foxy besides being a commander, but I wouldn't be surprised if Luffy takes it in bucket fulls.
The Amoeba Blaster doesn't really do anything special. It basically just acts as a different type of projectile, one that flies out randomly and bounces off surfaces. Really shouldn't have disease manipulation.