Hmm. I already argumented against his points, though.
I'll go into more detail if it's needed, starting with the IG.
IG has Reality Warping. Life & Death Manipulation. Precognition. Space-Time Manipulation. Mind Manipulation. Matter Manipulation. Soul Manipulation. Conceptual Manipulation. Existence Erasure. It also grants the user Omniscience and Omnipresence.
However... Reality Warping is directly countered by the Loli's own passive Reality Warping, whatever changes Derpy makes, the Loli naturally goes against them parallel to his own super-imposed perceptual-filtered version of reality interactions.
Life & Death Manipulation is something characters much weaker than the Loli have "healed" themselves from and he scales much, much higher than them. The weak one in question was paradoxically infused to his core with someone who is already dead, entering a perpetual state of "forced death" they were able to reover themselves from.
Precognition with the IG works due to the user viewing all of story across space and time at once, this won't do anything because the Loli is disconnected (Acausality) from space and time, Derpy won't be able to see the Loli's immediate attacks.
Space-Time Manipulation is practically useless against him, he violently resists changes on his coordinates (Acausality), so things like traveling back in time to kill him, stopping time to attack him, or sending him into a parallel reality, as means to BFR him, for example, wouldn't work as they should, not just due to resistances, but because he can simply "walk" back to the arena.
Mind Manipulation against someone like him, as I've explained earlier, won't just work, the "Mind" that the IG takes into consideration won't be able to properly put a certain state of mind on him, due to the amalgamation of emotions and thoughts that make up the Loli, plus, even with a handicapped mentality, he is still instinctively driven to kill Derpy, making no changes in the actual fight. The lose of the Loli's Mind, being just an aspect of him, won't really handicap him.
Matter Manipulation suffers a similar problem, the "matter" the Loli us made from is inseparable from himself, in other words, even the smallest "thing" that composes the Loli has the same characteristics as him, they ARE him, so if Derpy were to, say, snap the Loli into atoms like Thanos would, now you will have billions upon billions of Loli atoms trying to fight against him, and if Derpy were to turn, say, the Loli into bubbles, you have a sea of murderois bubbles going against Derpy. The lose of the Loli's Body, being just an aspect of him, won't really handicap him.
Soul Manipulation is similar to the problem above, the Loli has ridiculous amount of control over his soul, if he were to be absorbed by the Soul Stone, he would carve his way out of the stone or just LOAD back to where he previously was, not to mention every other aspect of his being would be fighting still. The many attacks the Loli can unleash will continue. The lose of the Loli's Soul, being just an aspect of him, won't really handicap him.
Conceptual Manipulation is the same as above, the Loli can deal with conceptual damage, take hits from it, counter with his own, and actively regenerate from it, just like any other aspect of his being. The lose of the Loli's Concept, being just an aspect of him, won't really handicap him.
Existence Erasure would be the same thing as applying Life & Death Manipulation, he can just take EE (and even NEE) hits normally, hs the stamina to continue from that point and then heal from it.
Omniscience here means nothing. It's based on the user's ability to see all of time and space at once like the Precognition, which isn't effective against the Loli's shenanigans with SAVE & LOAD and his own weird mix of acausality. The many attacks the Loli unleashes will be unknown to the user, disconnected from the spatiotemporal cause and effect (and a bit of messing with logic).
Now onto his YouTube Summoning... well, he's going to summon more people to the battlefield... in the middle of a fight against someone that can insta-kill with basically every move he does and gets stronger and more effective at it the more people he kills. That is a very bad idea for Derpy unless he wants to lose faster.
Delet This is like a meme version of Existence Erasure, but he negs it the same way as the others if we take it as a serious power, if we take it in the meme way, the meme never really manages to delete things, only tries to persuade the other into deleting them, the other can just laugh and repost it again. Not very useful IMO.
No U is a meme version of Attack Reflection, but suffers the same issues I posted above, the card will get shredded to bits as what the Loli does kinda violates the definition of attack in the first place.
Ralsei is, funny enough, an actual viable strategy here lol, but there's a trick. Derpy could potentially make the Loli stop fighting to hug Ralsei, as long as Ralsei doesn't act different than he does in canon, if he, for example, has a gun, this Ralsei will die, instantly. Anyway, the trick here is that, summoning Ralsei could work, but the win conditions is via Death or K.O. and summoning Ralsei does neither.