It’s definitely a similar kind of fight, mostly because SAVE/LOAD will still play a major role here. And it's probably not all that big of game changer considering sans has a 1–1 record against people who can SAVE/LOAD (Beat Flowey, Lost to Frisk).
Character-wise, while Frisk and Flowey were primarily driven by curiosity, Genocide Clover sees every monster as responsible for the deaths of the six fallen humans and acts as a self-appointed executioner. Because of that, sans' KARMA (The guilt part of it) will probably hit Clover harder than it hit Frisk or Flowey.
Mechanically, Clover is also a lot more versatile than Frisk was during their sans fight. They have healing ACTs, can dash, and Yellow Mode allows them to attack during the sans's turn (Though Blue Mode could potentially screw with that). Plus, being LV 20 means Clover has 99 HP, a slight edge over Frisk.
On the flip side, Clover is a lot slower. Even their shots which are several times faster than Clover themselves, are still twice as slow as Frisk was at the point they fought sans.