Since both of them have prior knowledge, TWOS (shortening The Worker of Secrets) will be extremely careful of Wolf's Red Mortal Blade, as it's going to mess his day up a whole lot. His armor has got it covered, I believe, as it's not showing any skin and he should be able to withstand some hits. His AnPr might give Ookami some trouble, but by how versatile the latter is (especially in the mid-game and with prior knowledge), he's going to succumb to Wolf's blade before he can AnPr his whole skillset.
I'm not sure if TWOS' immortality negation will work on ninja boi since it doesn't negate type 8 (the dragon heritage). If it doesn't work, Sekiro will be on his tail regardless of how many times he dies, even getting a sneaky hit on the guy. Either that, or he gets Dragonrot. However, if his immortality negation does work, Sekiro fecking dies if TWOS lands a single hit with the blade or his Quantum Destabilizer.
On Wolf's side, he's going to avoid getting hit by the immortality-negating equipment the other combatant has, regardless of their effectiveness on him. Probably because of prior knowledge, he'll amp himself up with all the candies and the divine confetti before finally clashing blades.
Most of his prosthetics are going to be a big help, specifically the Flame Vents, Umbrellas, Fire Crackers and the Mist Raven. I think his spears and axes may be able to deal with his armor and defenses (moreso his spear, as his axe is mostly stated to break wooden shields). Shurikens for long-range poking and maybe even the divine abduction can find some usage by turning him back to get funny backshots some good hits on TWOS.
Since Sekiro has the AP advantage (seriously how do people get the exact AP amount?), compared to TWOS' City Block Level + with the former's Multi-City Block Level, he should be able to get some good hits before landing the finishing blow with the mortal blade.
This certainly is quite the matchup!
Edit: I just found out the forum censors swear words!